Lexicon Bio

lexicon

/ˈlɛk.sɪ.kən/ n.  the vocabulary of a language

Building a platform that speaks the language of cells.

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platform

  1. Targeted transcriptional editors are tools with extraordinary potential but massive delivery challenges. Lexicon is building a platform for transcriptional editing using small molecules that can go anywhere in the human body.
  2. modular chemistryOur bifunctional editors can be built iteratively and rapidly using modular library synthesis.
  3. transcriptome-scale profilingEach molecule is profiled transcriptome wide, surfacing on and off target biology. Data of unparalleled richness and relevance for rapid optimisation and early derisking.
  4. discovery engineBuilt to turn high-throughput experiments into actionable decisions. Rapid library iteration is coupled to a massive and growing dataset of transcriptional data.

pipeline

  1. oncologyMetastatic castration-resistant prostate cancer. Repressors of an undruggable transcription factor.
  2. regenerative medicineHeart failure with reduced ejection fraction. Activators of a regenerative stem-cell pathway.
  3. immunologyInflammatory bowel disease. Precise control of a master immune regulator.

team

London

–Alfie Brennan, PhD · founder. Medicinal chemist with ten years designing and optimising bifunctional molecules, and a second-time founder. Led the identification of the first degraders of MDM2 and RIPK1; built Evariste's ML-first discovery platform from the ground up and led the team that identified preclinical-candidate PKMYT1 inhibitors.

–Andy Crew, PhD · scientific advisor. First chemistry employee and former CTO of Arvinas, the pioneering degradation company. Assembled and led the team that unlocked oral bioavailability for bifunctionals. Thirty years leading teams in pharma and biotech and supporting successful IPOs and exits.

–Jean-Christophe Harmange, PhD · scientific advisor. SVP of Drug Discovery at Psithera; previously CSO of Triana Biomedicines and Director of Drug Discovery at Constellation Pharmaceuticals. Thirty years leading teams in pharma and biotech, working on epigenetic targets and novel modalities.

–Genghis Lloyd-Harris, MD PhD · advisor. Investment banker and physician scientist with thirty years of transatlantic experience of company building. Investor in residence at Cancer Research Horizons; partner at Abingworth for twenty years and fifteen years at Credit Suisse.

blog

  1. April 2026The vision for Lexicon Bio

contact

  1. emailinfo@lexiconbio.com
  2. chemists, biologists, people who build instrumentsIf you want to work on this, write to us. Say what you have built.